Can we come out with some new simulation setup,which can give the output taking all factors into consideration.

Like for an opamp,

Common Mode signal,differential signal, noise,power supply coupling,transient behaviour. This will help us more than just check each one individually.

It was just an idea.

Comments are welcome.

I think the idea is good . One might argue that analog design is so special, but in reality it is not sooo much, just

references for I & V, power-on reset blocks

amplifiers: audio PA, RF PA, op-amps, transimpedance, OTA, VGA, PGA, level-shifters, voltage regulators, buffers, instrumentation amps, comparators, latched- comparators, gyrators, limiters, charge-amps, LNAs,

oscillators, VCOs, CCOs, xtal osc, temp sensors, quadrature generators, frequency multipliers, dividers, random generators, switches, S&H, T&H

mixers, rectifiers, modulators, exp/log-amps, sqr/sqrt circuit, RSSI circuits, pfd, charge-pumps,

sub-systems like filters, PLL, DLL, ADC, DAC, RF receivers, transmitters, SMPS, dc-dc converters

On each and any there are hundreds of good papers, and at the end what counts is power consumption, accuracy, linearity, noise, dynamic range, etc. within usal constraints (costs, load, supply, temperature, technology, time..).

I think it is not that complex . Just step-by-step.
However, the major requirement is indeed flexibility .

I think it is like music. The fundamentals are just tones with 20...20kHz spaced & modulated in time created by different means.
Bye Stephan