Mayank
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Hello rajesh, The break-down voltage is a limiting voltage above which Source & Drain starts exhibiting very high conductance because of avalanche/Zener Breakdown Effect...In all applications including RF/Analog, we always operate much below the breakdown Voltage..... Special care must be taken to ensure that voltage across any two MOS terminals should not go above the rated operation voltage(like 3.3V mos, 2.4V MOS, 1.2V MOS)....Esp in the case of a change in supply domain, like at the inputs as Tosei suggested, we place special ESD/CDM devices to ensure that the MOSFETs never come under stress.... i think that should suffice....
--Mayank
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