Variance between simulation and silicon.
Start with the premise that the weak-strong model corners
already have a lot of variance.
Will you be inside those limits if you include
everything in the model?
Generally yes. Give the below a read, it should help
you set up your model properly.
http://electronicdesign.com/article/eda/simulation-vs-silicon-avoid-costly-mista...Here's the original PDF (easier to read):
effectiveelectrons.com/whitepapers/simulationvssilicon.pdf
That might be useful background.