Hi, reading this article from 5/17/2007 now - 2012 - I think not much has changed at all!!!

For most non-trivial circuits, like having 40 transistors most autoplacer fail, although a good designer can find a solution quickly. The constraint concept ends up with adding more and more constraints, till you have no overview anymore or run into over-constraintment or tool problems!
Take a look at "Deterministic Analog Circuit Placement using Hierarchically Bounded Enumeration and Enhanced Shape Functions", 2010. This paper describes an advanced placer, but the created layout would NEVER survice a real-world design review :'(.
It seems that our PhD workers like to create new and more algorithms, but not even have criteria or benchmark to decide what a good layout is!
Bye Stephan